THE EVOLUTIONARY CONSERVATION OF THE CORE COMPONENTS NECESSARY FOR THE EXTRINSIC APOPTOTIC SIGNALING PATHWAY, IN MEDAKA FISH

The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish

Abstract Background Death receptors on the cell surface and the interacting cytosolic molecules, adaptors and initiator caspases, are essential as core components of the extrinsic apoptotic signaling pathway.While the apoptotic machinery governing the extrinsic signaling pathway is well characterized in mammals, it is not fully understood in fish.R

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Differences between the European Union and United States of America in Drug Regulatory Affairs Affect Global Patient Safety Standards and Public Health Awareness: The Case of Deferasirox and Other Iron Chelating Drugs

Regulatory policies on drugs have a major impact on patient safety and here survival.Some pharmaceutical companies employ all possible methods to achieve maximum sales in relation to the monopoly of their patented drugs, leading sometimes to irregularities and illegal activities.Misinformation on the orphan drug deferasirox has reached the stage of

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Annual Climatology of the Diurnal Cycle on the Canadian Prairies

We show the annual climatology of the diurnal cycle, stratified by opaque cloud, using the full hourly resolution of the Canadian Prairie data.The opaque cloud field itself has distinct cold and warm season diurnal climatologies; with a near-sunrise peak of cloud in the cold season and an early afternoon peak in the warm season.There are two primar

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Expensive Ornaments or Essential Technology? A Qualitative Metasynthesis to Identify Lessons From User Experiences of Wearable Devices and Smart Technology in Health Care

This review sought to describe experiences of using wearable devices worn on the body for the purpose of tracking health status and movement and or using in-home health-related smart technologies.In this qualitative metasynthesis, five databases were searched from database inception to May 11, 2022.Included were qualitative studies of the experienc

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